Comparison of prognostic outcomes in vitrectomy for myopic foveoschisis with foveal detachment: air tamponade versus no-air tamponade
Zhang J, Chang H, Liu S, Huang X, Chang Q.
Int J Retina Vitreous. 2026 Jun 27;12(1):127. doi: 10.1186/s40942-026-00884-5.
Summary
PPV for myopic foveoschisis with foveal detachment: Air (vs no air) tamponade increased early anatomic recovery, but similar long-term anatomic and VA outcomes — Retrospective, 47 eyes
Abstract
Purpose: To compare the efficacy of pars plana vitrectomy with or without air tamponade for patients with myopic foveoschisis (MFS) and foveal detachment (FD).
Methods: Forty-seven patients (47 eyes) with MFS and FD who underwent PPV with fovea-sparing internal limiting membrane peeling were included in this retrospective analysis. Patients were divided into air-tamponade (n = 21) and no-air-tamponade (n = 26) groups. Central foveal thickness (CFT), external limiting membrane (ELM) / ellipsoid zone (EZ) integrity, best-corrected visual acuity (BCVA), and incidence of complications were compared.
Results: In longitudinal analysis, the air-tamponade group had significantly faster CFT reduction at 1 week and 1 month (both P < 0.05). By 3 and 12 months, the CFT values were comparable between groups. Time to foveal reattachment was shorter with air tamponade (P < 0.001). The ELM and EZ integrity were compared at 12 months (both P > 0.05). Postoperative BCVA showed significant improvement from baseline at 3 and 12 months in both groups (P < 0.05). The time-by- tamponade type interaction at 3 and 12 months was not significantly different on BCVA in multivariable model (P > 0.05). Baseline diameter of FD was identified as an independent risk factor of 12-month BCVA by multivariable analysis. Complication rates, including postoperative macular hole, macular hole with retinal detachment, and transient aggravation, did not significantly differ between groups.
Conclusion: Air tamponade accelerated early anatomical recovery in MFS with FD, but both tamponade types achieved comparable long-term anatomical and visual outcomes. Baseline FD diameter was the independent predictor of visual outcome.