This 75YO female has a history of bilateral uveal malignant melanoma and is now monocular following enucleation of her left eye in 2001.
Plaque therapy in 2011 successfully saved her right eye, and the tumor has completely regressed.
Unfortunately, vision is 20/200 due to prior radiation retinopathy and possible glaucomatous optic neuropathy.
Learning Points:
In the United States, uveal malignant melanoma has an incidence of about 1 in 5 million people per year, and is virtually always unilateral. Primary bilateral uveal melanoma, as in this patient, is exceedingly rare (see Scott et al, Clin Exp Ophthalmology 2018;46:502-510). The BAP1 (BRCA-associated protein 1) germline mutation may be implicated in these cases.
