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RPE HAMARTOMA

Nikolaos Zagorianos

Originally posted on @retina.rocks 02/05/2026

This 38YO male was referred for an asymptomatic lesion in his left eye. Vision was 20/25 in his normal OD and 20/25 OS.

Optos color RG imaging shows a small foveal hyperpigmented lesion that hypo-autofluoresces. Triton swept-source OCT shows a markedly hyperreflective intraretinal lesion that protrudes above the retinal surface with marked posterior shadowing. Observation was recommended.

Learning Points:
RPE hamartoma is an extremely rare, benign, presumed congenital lesion. It appears as a small, jet-black inner vs full-thickness foveal or juxta-foveal retinal lesion (Shields et al, Ophthalmology 2003;110:1005-1011). These lesions are markedly hyperreflective on OCT (Takahashi et al, Retinal Cases & Brief Reports 2013;7:179-182).