This is a 3YO female with a history of bilateral retinoblastoma and prior enucleation of the right eye. It is a follow-up of a previously posted case (11/7/21).
Optos imaging of the left eye shows an active retinoblastoma with complete regression following 6 months of treatment, which included intra-arterial chemotherapy and cryotherapy.
Learning Points:
Small tumors can be treated with focal therapies such as laser therapy, cryotherapy, or radioactive plaque therapy.
Larger tumors are treated with chemotherapy (most commonly intra-arterial through the ophthalmic artery and occasionally systemic). Chemotherapy has dramatically decreased the need for enucleation.

