This 3YO female has a history of bilateral retinoblastoma and prior enucleation of the right eye. Optos color RG imaging of her left eye shows a still active retinoblastoma, despite prior treatment, which included intra-arterial chemotherapy and cryotherapy.
Learning Points:
Small tumors can be treated with focal therapies such as laser therapy, cryotherapy, or radioactive plaque therapy.
Larger tumors are treated with chemotherapy (most commonly intra-arterial through the ophthalmic artery and occasionally systemic). Chemotherapy has dramatically decreased the need for enucleation.

